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Medical Innovation Exchange

Bristol Myers buoys cell therapy interests with $3B biobucks deal with Bayer-backed Century, $70M upfront to ArsenalBio

Is it a once-in-a-century bet? Bristol Myers Squibb will throw in as much as $3 billion for Century Therapeutics’ cell therapies and is doling out at least $70 million for ArsenalBio’s.

The two deals are part of a flurry of announcements that have kicked off the virtual J.P. Morgan Healthcare Conference. 

The New York Big Pharma is paying $100 million upfront and investing $50 million in Century to make up to four programs to treat blood and bone marrow cancers and solid tumors. The deal could balloon to more than $3 billion for the public biotech with biobucks and commercial milestone payments. 

BMS is linking arms with the Bayer-backed Philadelphia biotech to develop potential natural kill cell, iNK, and/or T-cell programs, the companies said Monday. BMS has the option to add two more programs.

BMS’ executive vice president and president of early R&D, Rupert Vessey, said Century’s cell therapies are “complementary to” the Big Pharma’s existing cell therapy technologies. 

RELATED: Bristol Myers doubles down on Immatics with new $770M biobucks collab for solid tumor bispecific

Up first, the companies will tackle acute myeloid leukemia, a cancer of the blood and bone marrow, and multiple myeloma, which attacks the plasma cells. Century will handle everything preclinical, and BMS will take the reigns on clinical and commercial development. 

The induced pluripotent stem cell biotech emerged with $250 million from Bayer’s VC arm and Versant Ventures in July 2019. Century deployed some of that capital on buying Empirica in June 2020 to make a CAR-T treatment for glioblastoma. 

Also catching the eyes of the Big Pharma early in the new year is ArsenalBio. The Bay Area biotech is developing programmable cell therapies. BMS’ second deal on Monday also centers around solid tumors and ArsenalBio’s T cell therapies. 

RELATED: Bayer-backed Century buys Empirica to create brain cancer CAR-Ts

The multi-year discovery collaboration gives BMS the option to obtain an exclusive worldwide license to develop and market preclinical candidates. Terms of the potential milestone payments were kept under wraps. 

ArsenalBio launched with $85 million from Westlake Village BioPartners and others in October 2019. 

Solid tumors are a solid bet for BMS. The Big Pharma is testing more than a dozen assets including its branded drug Opdivo in about 30 different solid tumor tests. The company also has more than a few studies in AML and multiple myeloma. 

The two cell therapy deals come after BMS snagged two CAR-T approvals from the FDA last year for large B-cell lymphoma drug Breyanzi and multiple myeloma treatment Abecma, in partnership with bluebird bio.

Kyle LaHucik

https://www.fiercebiotech.com/biotech/bristol-myers-signs-3b-biobucks-deal-century-for-cell-therapies-for-hematologic-solid

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